- Country: USA
- Summary: Association of Sex Steroid Hormones and Gallbladder Cancer in Women
- UST Ref No: 86003941
- Deadline: 02 Aug 2023
- Financier: Self Financed
- Purchaser Ownership: Government
- Tender Value: Refer Document
- Notice Type: Tender
- Document Ref. No.: 75N91023Q00137
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- Description:
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Contracting Office Address
The Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Rockville, MD 20850, UNITED STATES
1.0 DESCRIPTION The Division of Cancer Epidemiology and Genetics (DCEG) plans to procure services, on a sole source basis, from Universite Laval, Pavillon Des Sciences De L'EDUCATION, Room 1434, 2320 Rue Des Bibliotheques, Quebec, Qc G1V 0A6, Canada.2.0 BACKGROUND
Gallbladder cancer (GBC) has a female predominance with a worldwide femaleβtoβmale incidence rate ratio of 2:1. This sex disparity suggests that sex hormones may be involved in carcinogenesis. Several studies have shown that reproductive factors (proxies for endogenous hormone levels) among premenopausal women are associated with an increased risk of GBC. Estradiol is a primary sex steroid hormone that regulates diverse biological processes and is critical for reproduction and hepato-biliary secretion. In postmenopausal women the main source of estrogen in circulation is from conversion of androgens to estrogens in adipose tissue due to aromatase. The lithogenic effect of estradiol is dose-dependent and acts by upregulating the expression of estrogen receptor-Ξ± (ERΞ±). Estradiol increases hepatic output of newly synthesized cholesterol, resulting in increased transfer of cholesterol to bile, increasing the risk of in chronic inflammatory gallbladder disease. Chronic inflammation of the gallbladder causes epithelial regeneration with metaplasia to subsequent development of dysplasia, carcinoma in situ, and invasive carcinoma. The progression from metaplasia to dysplasia may be sex hormone dependent. The overexpression of progesterone and estrogen receptors has been observed in studies of GBC. Progesterone receptor expression was seen in a higher proportion of cases with metaplasia compared to those without metaplasia and higher ER expression was seen in malignant lesio... - Documents:
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CLICK HERE TO LOGINAssociation of Sex Steroid Hormones and Gallbladder Cancer in Women - USA Tender
The HEALTH AND HUMAN SERVICES, DEPARTMENT OF, a Government sector organization in USA, has announced a new tender for Association of Sex Steroid Hormones and Gallbladder Cancer in Women. This tender is published on USARFP under UST Ref No: 86003941 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2023-08-02.
The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.
