- Country: USA
- Summary: Autoantibody Profiles and Polyautoimmunity in Aging
- UST Ref No: 125274491
- Deadline: 03 Sep 2025
- Financier: Self Financed
- Purchaser Ownership: Government
- Tender Value: Refer Document
- Notice Type: Tender
- Document Ref. No.: 75N95025Q05864
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- Description:
- Description
Autoimmune diseases are a leading cause of chronic illness and disability, particularly among women and older adults. Many individuals develop more than one autoimmune condition, a phenomenon known as polyautoimmunity. Polyautoimmunity is associated with greater disease burden, more complex treatment needs, and heightened immune dysregulation. Despite its importance, it remains poorly understood, especially in aging populations.
This project will evaluate whether older adults with polyautoimmunity demonstrate unique or intensified autoantibody patterns, and whether specific immune signatures are linked to aging outcomes such as frailty and multimorbidity. The BLSA, with its deeply phenotyped cohort and biobanked serum samples, provides an ideal setting for this work.
The contractor shall construct and perform antibody array testing using a high-throughput immunoproteomics approach for
1,700 proteins targeting selected autoantigens in 270 blood samples. The contractor must construct and perform antibody assays for tens of thousands of antigens in hundreds of samples AND for hundreds of antigens in tens of thousands of samples. The contractor should support data analysis and interpretation. The contractor needs to be proficient in high-throughput multiplex assays for disease-associated antibodies, as demonstrated by peer-reviewed publications, meeting presentations, and/or other scientific reports.
Specific requirements for the assay platforms are as follows.
Well-folded and often functional protein antigens, including conformational epitopes Use of freshly produced full-length antigens Easy data interpretation of target antigens of disease-associated antibodies Flexible and expedient adjustment of antigen contents Flexible with producing antigens using different expression systems Capable of assaying both human and microbial antigens simultaneously High-yield protein features with high sensitivity Quantitatively reproducible Comp... - Documents:
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CLICK HERE TO LOGINAutoantibody Profiles and Polyautoimmunity in Aging - USA Tender
The HEALTH AND HUMAN SERVICES, DEPARTMENT OF | NATIONAL INSTITUTES OF HEALTH, a Government sector organization in USA, has announced a new tender for Autoantibody Profiles and Polyautoimmunity in Aging. This tender is published on USARFP under UST Ref No: 125274491 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2025-09-03.
The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.
