Tender Details

Country: USA
Summary: Effect of Radiation Quality and Galactic Cosmic Radiation Simulation on the Risk of Carcinogenesis in an Outbred Mouse Model (HS/Npt)
UST Ref No: 126160815
Deadline: 18 Sep 2025
Financier: Self Financed
Purchaser Ownership: Government
Tender Value: Refer Document
Notice Type: Tender
Document Ref. No.: 80JSC025IRM001
Purchaser's Detail:
Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details. Login to see full purchaser details.
Login to see details
Description:
Description
1. Background
Astronauts on long-duration space missions are exposed to galactic cosmic rays (GCR) and solar particle events (SPE), creating elevated risks of carcinogenesis, cardiovascular disease (CVD), and central nervous system (CNS) decrements. Traditional inbred animal models have limitations due to genetic uniformity, potentially leading to overestimation of relative biological effectiveness (RBE). Outbred mouse models (HS/Npt) provide a genetically diverse system that better mirrors human populations and may yield more accurate assessments of radiation-induced cancer and related health risks.
2. Objectives
The objectives of this study are to:1. Determine the effects of radiation quality, dose, and dose rate on cancer initiation, promotion, and progression in HS/Npt outbred mice.2. Establish RBEs and quality factor estimates for space-relevant radiation exposures.3. Provide biobanked tissue and comprehensive metadata to support future NASA investigations.4. (Optional) Assess cardiovascular and CNS outcomes, as well as sex-specific responses, within budget constraints.
3. Scope of Work
The Principal Investigator (PI) shall design and execute experiments utilizing outbred HS/Npt mice supplied by NASA. Work shall include:- Radiation exposures at technically acceptable laboratory (See attached laboratory technical acceptability requirements sheet), including gamma irradiation, full GCR simulation (acute and fractionated), and single-ion exposures (e.g., 56Fe) where justified.- Dose coverage relevant to Mars design reference missions (300-450 mGy).- Survival, tumor incidence, and tumor spectrum analyses.- Comprehensive tissue collection, preservation, and metadata management.- Biobanking of required samples per NASA specifications.- Preparation of interim and final reports.
This is stricly a request for information. The Government has no obligation for award. If interested please provide a capabilities statement.
Documents:

If you are registered member, kindly login to view full details of this tender notice:

Effect of Radiation Quality and Galactic Cosmic Radiation Simulation on the Risk of Carcinogenesis in an Outbred Mouse Model (HS/Npt) - USA Tender

The NATIONAL AERONAUTICS AND SPACE ADMINISTRATION, a Government sector organization in USA, has announced a new tender for Effect of Radiation Quality and Galactic Cosmic Radiation Simulation on the Risk of Carcinogenesis in an Outbred Mouse Model (HS/Npt). This tender is published on USARFP under UST Ref No: 126160815 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2025-09-18.

The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.