- Country: USA
- Summary: Leica Vibrating Blade Microtome or Equal
- UST Ref No: 85560516
- Deadline: 17 Jul 2023
- Financier: Self Financed
- Purchaser Ownership: Government
- Tender Value: Refer Document
- Notice Type: Tender
- Document Ref. No.: 75N95023Q00476
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- Description:
- Description
Leica Vibrating Blade Microtome or Equal
The purpose of this acquisition is for the Cellular Neurophysiology Section to purchase a vibrating blade microtome microscope system that will allow the examination of the mechanisms of synaptic integration and dendritic information in dopamine neurons located in the midbrain.
Our lab studies the neural mechanisms that underlie reward-based behaviors and reinforcement learning. Dopamine-releasing neurons in the midbrain play a critical role in these behaviors. In addicted animals, the dopamine system is "hijacked" by drugs of abuse that increase brain dopamine levels through direct or indirect actions on dopaminergic neurons. Furthermore, the selective loss of subsets of dopaminergic neurons leads to the severe motor deficits observed in patients with Parkinson-s Disease.
Our studies examine the physiological properties of dopamine neurons that a vulnerable and resilient to cell death in Parkinson-s Disease. In particular, our laboratory is interested in understanding how electrical activity of vulnerable and resilient dopamine system neurons is generated mechanistically and how this activity ultimately contributes to dopamine-dependent behaviors. We study (1) how ion channels, proteins that conduct ions across the cell membrane of dopamine neurons, and (2) how ligand gated receptors enable this electrical activity along with circuit connections that shape their activity during behavior. These studies have led to the identification of circuit, synaptic and intrinsic characteristics that differ between calbindin positive resilient dopamine neuron subpopulations and Aldh1a1 positive dopamine neurons that are vulnerable to cell death. We hope that these studies will advance our knowledge of functional diversity among dopamine neuron subpopulations and the mechanisms of selective vulnerability among neurons in the brains of patients inflicted with Parkinson-s Disease.
To study these... - Documents:
Sources-Sought-Notice--GSS-Leica.pdf
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CLICK HERE TO LOGINLeica Vibrating Blade Microtome or Equal - USA Tender
The HEALTH AND HUMAN SERVICES, DEPARTMENT OF, a Government sector organization in USA, has announced a new tender for Leica Vibrating Blade Microtome or Equal. This tender is published on USARFP under UST Ref No: 85560516 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2023-07-17.
The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.
