Tender Details

Country: USA
Summary: Nanobody Affinity Maturation using Phage Display Selection
UST Ref No: 123058406
Deadline: 01 Aug 2025
Financier: Self Financed
Purchaser Ownership: Government
Tender Value: Refer Document
Notice Type: Tender
Document Ref. No.: 75N91025Q00049
Purchaser's Detail:
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Description:
Description
The National Cancer Institute (NCI)-s Center for Cancer Research Office (CCR) Molecular Imaging Branch (MIB) plans to procure on a sole source basis services for targeted affinity maturation of an anti-human BCMA nanobody via phage display library construction and selection. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1) via request for written quotation.Only one (1) award will be made as a result of this solicitation. This will be awarded as a firm fixed price type contract. The Period of Performance is estimated to be a base period of six (6) months from the effective date stated in the award.
2.0 BACKGROUNDThe National Cancer Institute/Center for Cancer Research (NCI/CCR), Molecular Imaging Branch (MIB) is engaged in the development of radiolabeled nanobodies targeting clinically relevant tumor antigens for diagnostic and therapeutic applications. One of the current programs focuses on targeting B-cell maturation antigen (BCMA) in multiple myeloma. A parental anti-human BCMA nanobody was purchased and demonstrated promising preliminary binding in vitro and in vivo, but further affinity enhancement is required to support translational applications. The goal is to generate high affinity nanobody variants (based on the parental one), suitable for imaging and radiotherapy through affinity maturation using phage display.
3.0 OBJECTIVEThe Contractor shall perform targeted affinity maturation of an anti-human BCMA nanobody via phage display library construction and selection. The objective is to deliver five affinity-optimized nanobody sequences along with sufficient purified protein for in vitro and in vivo testing.
4.0 SCOPEThe Contractor shall perform nanobody affinity maturation using established phage display techniques. The project will be based on nanobody sequence provided by the Government and will encompass a series of integrated activities aimed at enhanc...
Documents:

Att-1-Nanobody-Affinity-Maturation-SOW-071825.pdf

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Nanobody Affinity Maturation using Phage Display Selection - USA Tender

The HEALTH AND HUMAN SERVICES, DEPARTMENT OF | NATIONAL INSTITUTES OF HEALTH, a Government sector organization in USA, has announced a new tender for Nanobody Affinity Maturation using Phage Display Selection. This tender is published on USARFP under UST Ref No: 123058406 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2025-08-01.

The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.