Nih Tetramer Core Facility Tender

• Country: USA
• Summary: Nih Tetramer Core Facility
• UST Ref No: 138713446
• Deadline: 14 Apr 2026
• Financier: Self Financed
• Purchaser Ownership: Government
• Tender Value: Refer Document
• Notice Type: Tender
• Document Ref. No.: 75N93026R00006
• Purchaser's Detail:
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• Description:
• Background
  The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), of the Department of Health and Human Services (DHHS) supports research related to the basic understanding of microbiology and immunology leading to the development of vaccines, therapeutics, and medical diagnostics for the prevention, treatment, and diagnosis of infectious and immune-mediated diseases. As part of this mission, NIAID requires continued operation of the NIH Tetramer Core Facility (TCF). The TCF is a centralized resource producing and distributing custom MHC multimer reagents for the biomedical research community. These reagents enable the sensitive and specific detection of antigen-specific T cells across a range of diseases, including autoimmunity, cancer, and infectious diseases. MHC multimers are powerful tools for the rapid, highly sensitive quantitation of antigen-specific T cells from blood or tissue samples. Traditional reagents are comprised of four identical biotinylated MHC molecules, each loaded with an antigen-specific peptide/ligand, tetramerized using a streptavidin-linked fluorophore (i.e., tetramers). Current production methods may also generate higher-order multimers, either as a byproduct of the multimerization process or through approaches specifically designed to produce MHC multimers with higher valency.
  The TCF is an essential resource for the biomedical research community, enabling precise characterization of antigen-specific T cell populations. It plays a key role in research aligned with DHHS priorities, including the study and treatment of chronic and complex diseases, such as food allergies, autoimmune diseases, cancer, narcolepsy, organ transplantation, and Alzheimer-s Disease. These efforts are central to advancing DHHS- mission to enhance health outcomes, improve quality of life, and reduce the burden of disease through scientific innovation.
  The NIH Tetramer Core Facility contract was initially aw...
• Documents:

 Tender Notice