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Tender Details
- Country: USA
- Summary: Synthesis of HNMT, NNMT intermediates and PK
- UST Ref No: 124399045
- Deadline: 19 Aug 2025
- Competition: ICB
- Financier: Self Financed
- Purchaser Ownership: Public
- Tender Value: Refer Document
- Notice Type: Tender
- Document Ref. No.: 75N95025Q00236
- Purchaser's Detail :
- Description :
- Description
NCATS is in need of custom synthesis and bioanalytical services in internal projectsfocused on developing small molecule inhibitors of physiological small moleculemethyltransferases. NACTS is pursuing small molecules in two projects wheremethyltransferases are implicated in disease. NCATS requires key intermediates thatwill allow for the lab to scale up lead compounds or make analogs. NCATS also requiresexposure data in various tissues of interest to gauge compound concentrations to selectcompounds for POC.100g of N-(pyridin-3-yl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-e][1,4]diazepin-8-amine100g of (tert-butyl (R)-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3- yl)piperidine-1-carboxylate.Mouse PK on at least 10 compounds with routes and tissues determined.The final purity has to be 95% with optical purity 98%. Spectroscopic characterizationand analytical data will be required and verified. - Documents :
Purchaser : HEALTH AND HUMAN SERVICES, DEPARTMENT OF | NATIONAL INSTITUTES OF HEALTH
c/o 3WFN MSC 6012 301 N Stonestreet Ave, Bethesda , MD 20892, USA
Primary Point of Contact: Andrew Varley, andrew.varley@nih.gov, Phone Number 3018275851
Secondary Point of Contact: Joshua T. Lazarus, Josh.Lazarus@nih.gov, Phone Number 301827...
Email :andrew.varley@nih.gov
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