Tender Details

Country: USA
Summary: Synthesis of HNMT, NNMT intermediates and PK
UST Ref No: 124399045
Deadline: 19 Aug 2025
Financier: Self Financed
Purchaser Ownership: Government
Tender Value: Refer Document
Notice Type: Tender
Document Ref. No.: 75N95025Q00236
Purchaser's Detail:
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Description:
Description
NCATS is in need of custom synthesis and bioanalytical services in internal projectsfocused on developing small molecule inhibitors of physiological small moleculemethyltransferases. NACTS is pursuing small molecules in two projects wheremethyltransferases are implicated in disease. NCATS requires key intermediates thatwill allow for the lab to scale up lead compounds or make analogs. NCATS also requiresexposure data in various tissues of interest to gauge compound concentrations to selectcompounds for POC.100g of N-(pyridin-3-yl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-e][1,4]diazepin-8-amine100g of (tert-butyl (R)-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3- yl)piperidine-1-carboxylate.Mouse PK on at least 10 compounds with routes and tissues determined.The final purity has to be 95% with optical purity 98%. Spectroscopic characterizationand analytical data will be required and verified.
Documents:

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Synthesis of HNMT, NNMT intermediates and PK - USA Tender

The HEALTH AND HUMAN SERVICES, DEPARTMENT OF | NATIONAL INSTITUTES OF HEALTH, a Government sector organization in USA, has announced a new tender for Synthesis of HNMT, NNMT intermediates and PK. This tender is published on USARFP under UST Ref No: 124399045 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2025-08-19.

The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.