- Country: USA
- Summary: TECHNOLOGY/BUSINESS OPPORTUNITY Automated High Throughput Screening Platform
- UST Ref No: 112766208
- Deadline: 06 Feb 2025
- Financier: Self Financed
- Purchaser Ownership: Government
- Tender Value: Refer Document
- Notice Type: Tender
- Document Ref. No.: IL-13845
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- Description:
- Description
Opportunity:
Lawrence Livermore National Laboratory (LLNL), operated by the Lawrence Livermore National Security (LLNS), LLC under contract no. DE-AC52-07NA27344 (Contract 44) with the U.S. Department of Energy (DOE), is offering the opportunity to enter into a collaboration to further develop its automated high throughput screening platform.
Background:
Proteins, including antibodies, are increasingly becoming important as therapeutics. LLNL has developed an in silico antibody design platform based on AI tools. The approach requires experimental evaluation of in silico designed antibodies, which currently takes several weeks. There is a need to overcome this shortcoming and develop an automated and integrated platform that can accomplish this task rapidly.
Description:
LLNL inventors have developed a method and device for the high throughput screening of various chemical and biological entities using a novel combination of cell-free protein synthesis (in vitro transcription-translation), microencapsulation and optical interrogation. This includes automated sample handling, microemulsions, microfluidics manipulation, machine vision, and fluorescent interrogation. This automated system can be used to partition analytes into thousands of independent microdroplet reactions that are tracked and optically interrogated for assay activity. Since timing of droplet generation and position are known, an n-dimensional pooling strategy can be performed to increase screening throughput over the traditional 1:1 assay method. An optical interrogation method such as fluorescence correlation spectroscopy (FCS) can provide highly quantitative information for each reaction in real time (e.g., affinity constant for novel antibodies), significantly increasing the precision and quality of data that informs future models and experiments. The approach outlined will enable the feedback loop from experimental evaluations to occur in about 3 days rather ... - Documents:
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CLICK HERE TO LOGINTECHNOLOGY/BUSINESS OPPORTUNITY Automated High Throughput Screening Platform - USA Tender
The ENERGY, DEPARTMENT OF, a Government sector organization in USA, has announced a new tender for TECHNOLOGY/BUSINESS OPPORTUNITY Automated High Throughput Screening Platform. This tender is published on USARFP under UST Ref No: 112766208 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2025-02-06.
The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.
