- Country: USA
- Summary: TECHNOLOGY/BUSINESS OPPORTUNITY Insertional gene overlap for secure genetic engineering
- UST Ref No: 122346066
- Deadline: 08 Aug 2025
- Financier: Self Financed
- Purchaser Ownership: Government
- Tender Value: Refer Document
- Notice Type: Tender
- Document Ref. No.: IL-13898
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- Description:
- Description
Opportunity:
Lawrence Livermore National Laboratory (LLNL), operated by the Lawrence Livermore National Security (LLNS), LLC under contract no. DE-AC52-07NA27344 (Contract 44) with the U.S. Department of Energy (DOE), is offering the opportunity to enter into a collaboration to further develop and commercialize its “Insertional gene overlap for secure genetic engineering” technology.
Description:
Genetic engineering allows insertion and propagation of a foreign genetic element in a heterologous system in a variety of applications such as the creation of genetically modified organisms (GMOs) in the field of agriculture or production of therapeutic proteins and antibodies in the field of healthcare. However, such genetic insertions often lack the required stability to be maintained for long duration and are either mutated or lost. Another significant issue concerning such insert is the unwanted horizontal transfer to other organisms in the environment. Regulatory bodies such as FDA and USDA require demonstration of the stability and/or prevention of the horizontal transfer of such inserts. This LLNL invention describes an innovative design of a genetic unit that increases the stability of the insert as well as prevents unwanted horizontal transfer or spread of the insert to other organisms.
Advantages/Benefits:
Currently used approaches such as synthetic "gene entanglement" require complex bioinformatics, custom software, or model-based redesign of proteins with specific functions. As a result, that approach is inefficient and has a high failure rate. The approach described herein is sufficiently straightforward and robust to allow manual design of functional entangled protein pairs and is also amenable to automated software workflows that enable versatile design at scale.
Potential Applications:
Stabilization of engineered DNA to improve bioproduction processes Biocontainment of genetically modified organisms (GMOs) to l... - Documents:
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CLICK HERE TO LOGINTECHNOLOGY/BUSINESS OPPORTUNITY Insertional gene overlap for secure genetic engineering - USA Tender
The ENERGY, DEPARTMENT OF, a Government sector organization in USA, has announced a new tender for TECHNOLOGY/BUSINESS OPPORTUNITY Insertional gene overlap for secure genetic engineering. This tender is published on USARFP under UST Ref No: 122346066 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2025-08-08.
The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.
