Tender Details

Country: USA
Summary: Upgrade/Add-On Equipment: 4-Channel Laser Doppler Flowmetry System for Use with Existing Moor Instruments Near-Infrared Spectroscopy (Nirs) System
UST Ref No: 104448302
Deadline: 25 Jul 2024
Financier: Self Financed
Purchaser Ownership: Government
Tender Value: Refer Document
Notice Type: Tender
Document Ref. No.: NOI-NIAID-24-2231509
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Description:
Description
PRE-SOLICITATION NOTICE **NOTICE OF INTENT TO SOLE SOURCE
NOI-NIAID-24-2231509
NAICS - 334516

This is a Notice of Intent, not a request for proposal. The National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) intends to negotiate on an other than full and open competition basis with Moor Instruments Inc to purchase upgrade/add-on equipment, a 4-Channel Laser Doppler Flowmetry System, for use with an existing Moor Instruments near-infrared spectroscopy (NIRS) system in use by the Laboratory of Malaria Research Vaccine Research (LMRV).
The mission of the LMRV is to develop production processes for vaccine candidates as they pertain specifically to Malaria. Malaria is associated with disturbances in microvascular blood flow that lead to coma, lactic acidosis, and kidney injury. Some of the mechanisms of blood flow disturbance include adherence of infected red blood cells to the vascular endothelium, excessive clotting of blood in small vessels, and disruption of signaling by nitric oxide, which is an endogenous short-acting vasodilator. LMVR has identified that human vascular endothelial cells use hemoglobin to control the release of nitric oxide. They found that some of the genetic mutations in the alpha and beta globin genes that encode for hemoglobin are associated with differences in endothelial hemoglobin expression and differences in the extent of nitric oxide-dependent vasodilation. This raises the possibility that some of the hemoglobin variants that protect against severe malaria such as hemoglobin S (also known as sickle cell trait) or hemoglobin C, may confer protection by enhancing the release of nitric oxide from endothelial cells. The original studies were performed on human arteries that were surgically removed from patients and then studied under controlled laboratory conditions. To further elucidate how hemoglobin variants affect human arterial vasoreactivity, LMVR n...
Documents:

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Upgrade/Add-On Equipment: 4-Channel Laser Doppler Flowmetry System for Use with Existing Moor Instruments Near-Infrared Spectroscopy (Nirs) System - USA Tender

The HEALTH AND HUMAN SERVICES, DEPARTMENT OF, a Government sector organization in USA, has announced a new tender for Upgrade/Add-On Equipment: 4-Channel Laser Doppler Flowmetry System for Use with Existing Moor Instruments Near-Infrared Spectroscopy (Nirs) System. This tender is published on USARFP under UST Ref No: 104448302 and is categorized as a Tender. Interested and eligible suppliers are invited to participate by reviewing the tender documents and submitting their bids before the deadline on 2024-07-25.

The estimated tender value is Refer Document, and full details, including technical specifications and submission requirements, are provided in the official tender documents. Ensure all submissions meet the criteria outlined to be considered for evaluation.